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From: "Ian & Mary Logan" <>
Subject: Re: [DNA] Marker Mutation Rates
Date: Sun, 2 Nov 2003 09:10:38 -0000
References: <5.0.2.1.2.20031101090758.02583ba0@mindspring.com>


> Ron Lindsay, San Jose, CA started this thread and several people
have already joined in.

Hello Ron

Just a pennyworth ....

Some markers hardly ever, ever show 'mutations'. Why ?

A 'mutation' should be random - but clearly something affects
the rate. Might it be a 'spatial' effect with some parts of the
Y-chromosome being more protected, ie. spatially less
prominent, at the usual time of replication, and thereby less
prone to replication errors.

Other markers change from time to time, commonly +1,
probably a little less often by -1, and very occasionally
by +2 or -2.
And, in the odd case -3 seems to occur by preference
over +1, -1, +2 and -2 (how very strange!).

And, some markers change frequently - with perhaps some
of these changing just too often to be useful in genealogy.

FTDNA uses markers from each of these groups - which is
both interesting and useful.

Now back to one of your points ...
Surely, a frequently changing marker could go +1 in one
generation and -1 the next. But why worry. It is the known
differences that are useful.

Our little study at the Brooking Society
(see www.brookingsociety.org.uk should you wish)
is just one of the many one-name studies that is helping to find
the perfectly explained pedigree - and perhaps in time we will
understand everything better.

Comments anyone.

Ian




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