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Subject: [DNA] SNP/STR study of Native Americans
Date: Wed, 5 Nov 2003 12:37:01 EST


This abstract appeared at PubMed before the print version. Since one of the
articles is Mike Hammer, FTDNA will probably add this article to their Library
when it's available.

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Mol Biol Evol. 2003 Oct 31 [Epub ahead of print].

High Resolution SNPs and Microsatellite Haplotypes Point to a Single, Recent
Entry of Native American Y Chromosomes into the Americas.

Zegura SL, Karafet TM, Zhivotovsky LA, Hammer MF.

Department of Anthropology, University of Arizona, Tucson, Arizona 85721.

A total of 63 binary polymorphisms and 10 STRs were genotyped on a sample of
2,344 Y chromosomes from 18 Native American, 28 Asian, and 5 European
populations to investigate the origin(s) of Native American paternal
lineages.
All three of Greenberg's major linguistic divisions (including 342 Amerind
speakers, 186 Na-Dene speakers, and 60 Aleut-Eskimo speakers) were
represented
in our sample of 588 Native Americans. SNP analysis indicated that three
major
haplogroups, denoted as C, Q, and R, accounted for nearly 96% of Native
American
Y chromosomes. Haplogroups C and Q were deemed to represent early Native
American founding Y-chromosome lineages; however, most haplogroup R lineages
present in Native Americans most likely came from recent admixture with
Europeans. Although different phylogeographic and STR diversity patterns for
the
two major founding haplogroups previously led to the inference that they were
carried from Asia to the Americas separately, the hypothesis of a single
migration of a polymorphic founding population better fits our expanded
database. Phylogenetic analyses of STR variation within haplogroups C and Q
traced both lineages to a probable ancestral homeland in the vicinity of the
Altai Mountains in Southwest Siberia. Divergence dates between the Altai plus
North Asians versus the Native American population system ranged from 10,100
to
17,200 years for all lineages, precluding a very early entry into the
Americas.

PMID: 14595095 [PubMed - as supplied by publisher]




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