GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2003-11 > 1068579230


From:
Subject: Re: [DNA] DYS464 / new primer
Date: Tue, 11 Nov 2003 14:33:50 -0500 (EST)
References: <161.27f23266.2ce261b1@aol.com>
In-Reply-To: <161.27f23266.2ce261b1@aol.com> (DNACousins@aol.com)


Ann wrote:
[quoting Patrick]
> > The mutation-rate estimate based on the 70
> > meioses analyzed
> > amounts to 2.86?10-2 (95% confidence interval 3.5?10-3 to
> > 9.95?10-2). This value
> > is approximately 10 times higher than the average
> > mutation-rate estimate for
> > Y-STRs.
> >
> I assume the two mutations could
> have come from ANY of the four copies of DYS464. It seems to me that it would
> be more appropriate to divide the observed mutation rate by 4, since there were
> 70x4 opportunities to observe a mutation in the set.

I agree. Note that dividing by four moves the 95% confidence interval
as well, to (0.9e-3, 25e-3). In short, the interval spans the nominal
mutation rate. We are still a long way from pinning down rates for
indiviual markers.

John Chandler


This thread: