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From:
Subject: Re: [DNA] Mutation rate and distant ancestors
Date: Thu, 20 Nov 2003 16:28:04 -0500 (EST)
References: <571CF05B2EDBF4479C40CF29EC0C591E154BAC@exchange.conrad.local>
In-Reply-To: <571CF05B2EDBF4479C40CF29EC0C591E154BAC@exchange.conrad.local>(mharper@conrad.org)


Mike wrote:
> Well I match my third cousin (8 transmission events) 23 out of 25. The
> mismatch is by 1 at 459b and 464d (fast mutating markers). Since we have
> a paper trial showing our relationship, we need to use a faster mutation
> rate (say 0.004) to reach concordance between paper and DNA estimates of
> MRCA.

If I'm interpreting your tally correctly, you have 2 mutations in 200
opportunities. That's a rate of 0.01 +/- 0.01. You can't really say
much about the mutation rate with such a small sample.

John Chandler


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