Archiver > GENEALOGY-DNA > 2003-11 > 1069782441

From: "ernest hurst" <>
Subject: RE: [DNA] DNAPrint on Nightline -- error estimate seen on the certificate
Date: Tue, 25 Nov 2003 12:47:27 -0500

I thought I remembered something about a 5% error rate, and also that John
felt the error rate was probably 15 to 20%. Maybe I dreamed that, I don't
know. Also seem to remember that the DNA that they are measuring might, or
might not, be passes along to next generation - as in siblings with
entirely different results. Am I "disremembering" again, or is that
correct. If that is true, and the "tolerance" is as high as 20%, it might
shed a whole new light on the case being discussed.

Ernie Hurst

> [Original Message]
> From: Malcolm Dodd <>
> To: <>
> Date: 11/25/2003 6:27:26 AM
> Subject: [DNA] DNAPrint on Nightline -- error estimate seen on the
> DNAPrint say -
> >My proportions were 95% IndoEuropean and 5% East Asian, and the East
> part surprised me. How reliable is the 5% part of the profile?
> The 5% East Asian means you most likely share sequence identity with East
> Asians. From having run over 1,700 ancestrybydna tests we know to expect
> 3% error in your profile, almost all of it originating at the genotyping
> step. In rare cases where we have repeated analyses for a person over
> runs, we have observed an error rate as high as 5%, but this is rare
> is the norm. Nonetheless, to be conservative, it is probably best for
> customers to take values less than 5% with a grain of salt. They may be
> significant, but they may not be. The confidence contours on your
> plot show this to be the case at these low levels, there is always
> with 0% for this ancestry proportion. However, if you have a profile
with a
> low percent for a group, and it interests you, there are two things you
> do to confirm its significance which brings us to the next: question <
> Malcolm
> ==============================
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