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Archiver > GENEALOGY-DNA > 2007-06 > 1182442457


From: (John Chandler)
Subject: Re: [DNA] TMRCA Corrections
Date: Thu, 21 Jun 2007 12:14:17 -0400 (EDT)
References: <004101c7b33f$d2296bf0$6400a8c0@Ken1><REME20070620221136@alum.mit.edu> <010301c7b3b0$635e5110$6400a8c0@Ken1>
In-Reply-To: <010301c7b3b0$635e5110$6400a8c0@Ken1> (knordtvedt@bresnan.net)


Ken wrote:
> There is actually an N dimensional spheroid or ellipsoid like volume in
> haplotype space (N is number of markers) surrounding the original founder's
> haplotype and which grows in size as time goes by --- within this volume the
> percentage for each haplotype is falling and outside the volume the
> percentage for each haplotype is growing, and on the surface of this volume
> we have haplotype percentages which are momentarily not changing. So what
> you say in your paragraph above is only true in the extreme youth of the
> clade

Ah, but what is "extreme youth"? The frequency of each
one-step-off-modal allele should continue to increase until it is a
bit more than half the modal frequency. In other words, until the
model allele is no longer the majority. Isn't that what you would
call "mature"?

John Chandler


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