GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2008-12 > 1228678354


From: "Lancaster-Boon" <>
Subject: [DNA] DYS 710
Date: Sun, 7 Dec 2008 20:32:34 +0100


So why isn't DYS710 reported as two separate repeat numbers?

Regards
Andrew


------
From: (John Chandler)
Subject: Re: [DNA] DYS 710
Date: Sat, 6 Dec 2008 22:27:02 -0500
References: <>
In-Reply-To: <> ()

Bill wrote:
> What is the procedure for comparing DYS 710?

That's not established. 710 is more complex than most other markers
because it has repeats of two different sizes, two and four. A
difference that purports to be "one repeat" (of the four-base motif)
could actually be a difference of two repeats of the two-base motif.
Ordinary STR-type testing, which simply reports the length of the
marker, doesn't give you enough information to decode the marker.
You would need to sequence the PCR product every time, even if two
people seem to match.

I don't think anybody has even a good guess at the relative mutation
rates of the two motifs. Four-base STRs generally have higher rates
than two-base STRs, but there is also a dependence of rate on the
number of repeats, and there seems to be considerable variability in
both stretches.

John Chandler



This thread: