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From: steven perkins <>
Subject: [DNA] Article: Inspecting close maternal relatedness: Towardsbetter mtDNA population samples in forensic databases.
Date: Mon, 15 Nov 2010 22:29:08 -0500


There may be something of interest in this article for those
interested in using mtDNA for ancestry.
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Forensic Sci Int Genet. 2010 Nov 8. [Epub ahead of print]

Inspecting close maternal relatedness: Towards better mtDNA population
samples in forensic databases.

Bodner M, Irwin JA, Coble MD, Parson W.

Institute of Legal Medicine, Innsbruck Medical University, Müllerstr.
44, 6020 Innsbruck, Austria.
Abstract

Reliable data are crucial for all research fields applying
mitochondrial DNA (mtDNA) as a genetic marker. Quality control
measures have been introduced to ensure the highest standards in
sequence data generation, validation and a posteriori inspection. A
phylogenetic alignment strategy has been widely accepted as a
prerequisite for data comparability and database searches, for
forensic applications, for reconstructions of human migrations and for
correct interpretation of mtDNA mutations in medical genetics. There
is continuing effort to enhance the number of worldwide population
samples in order to contribute to a better understanding of human
mtDNA variation. This has often lead to the analysis of convenience
samples collected for other purposes, which might not meet the quality
requirement of random sampling for mtDNA data sets. Here, we introduce
an additional quality control means that deals with one aspect of this
limitation: by combining autosomal short tandem repeat (STR) marker
with mtDNA information, it helps to avoid the bias introduced by
related individuals included in the same (small) sample. By STR
analysis of individuals sharing their mitochondrial haplotype,
pedigree construction and subsequent software-assisted calculation of
likelihood ratios based on the allele frequencies found in the
population, closely maternally related individuals can be identified
and excluded. We also discuss scenarios that allow related individuals
in the same set. An ideal population sample would be representative
for its population: this new approach represents another contribution
towards this goal.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

PMID: 21067986 [PubMed - as supplied by publisher]


Related citations

Forensic genetic analysis of mitochondrial DNA hypervariable
region I/II sequences: an expanded Korean population database.
Jin HJ, Kwak KD, Hong SB, Shin DJ, Han MS, Tyler-Smith C, Kim W.
Forensic Sci Int. 2006 May 10; 158(2-3):125-30. Epub 2005 Jun 28.


--
Steven C. Perkins      
http://stevencperkins.com/
Online Journal of Genetics and Genealogy
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http://scpgen.blogspot.com/


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