GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2010-11 > 1290807910
From: "Diana Gale Matthiesen" <>
Subject: Re: [DNA] SNP Breakthrough for I1*-AS
Date: Fri, 26 Nov 2010 16:45:10 -0500
References: <email@example.com><003101cb8d8b$8c16b4e0$c2482dae@Ken1> <firstname.lastname@example.org><00df01cb8da4$e8ecd820$c2482dae@Ken1> <email@example.com><015401cb8db1$70725520$c2482dae@Ken1>
We have descended into a quibble over what "rare" means. How about
substituting, "rarely found"? Your own example makes the point: it took a
humongous expenditure of resources to find this single SNP.
Minor point: SNPs aren't "robustly dividing." A locus simply has or has not
mutated into the polymorphic state. 99.9% of the human genome is *not*
> -----Original Message-----
> From: [mailto:genealogy-dna-
> ] On Behalf Of Ken Nordtvedt
> Sent: Friday, November 26, 2010 4:33 PM
> Subject: Re: [DNA] SNP Breakthrough for I1*-AS
> ----- Original Message -----
> From: "Diana Gale Matthiesen" <>
> If SNPs are not
> > comparatively rare, making them difficult to find, why is finding one
> > such a "breakthrough"?
> Much of your question above should be addressed to those who spend the money
> and materials) to find snps right now.
> They don't come to be known to us for free. Just look at the economics of
> Searching 100,000 loci costs big bucks per person, even when the lab can count
> multiple searches on that same tiny segment of the y.
> But it does not take much counting to conclude snps are not rare in the full y
> simply waiting to be discovered.
> Now the folks in R1b...... are perhaps jaded by now with the number of snps
> their haplogroups during the last couple years, so whether a "breakthrough"
> happen for them, I don't know.
> But there has not been a robustly dividing snp found for I1* EVER until now
--- hence the
> "breakthrough" talk. (I don't mean to slight M227 which isolates a tiny
> I1 found preferentially in more easterly Europe. And L22, as useful as it is,
> retagged a robust division of I1 previously established on the basis of STR
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|Re: [DNA] SNP Breakthrough for I1*-AS by "Diana Gale Matthiesen" <>|